Is tardive dyskinesia a side effect of Haldol?

Yes since paliperidone is an antipsychotic medication and most antipsychotic drug exerts its effect by blocking dopamine receptor in the brain (excessive dopamine activity is believed to have caused psychosis). The target pathway is the mesolimbic pathway, however there are several more pathways in the brain which utilises dopamine and one of them is known as nigrostriatal pathway. Nigrostriatal pathway is required for “fine-tuning” motor activity and antipsychotic, which is a dopamine receptor blocker, will inadvertently block this pathway as well. This will cause a wide range of extra-pyramidal symptoms and tardive dyskinesia is one of them. Other symptoms would include dystonia and Parkinsonism (please keep in mind Parkinson’s disease is caused by death of neurons in the same area of nigrostriatal area known as substantial nigra)